Tr53 Haploinsufficiency Modifies EGFR-Driven Peripheral Nerve Sheath Tumorigenesis.

July 1, 2014
Authors: Rahrmann, et al.
B-MoGen Authors: Branden S Moriarity, Beau R Webber & David A Largaespada
Publication: The American Journal of Pathology. 184(7): 2082-2098.
Published Date: July 2014
Establishes link between TP53 deficiency and EGFR overexpression in nerve sheath tumorgenesis.
In individuals with inherited tumor predisposition syndrome neurofibromatosis type I (NF1), malignant peripheral nerve sheath tumors (MPNSTs) are a significant risk. This study aimed at determining the cooperativity between TP53 underexpression and EGFR overexpression in vitro (immortalized human Schwann cells) and in vivo (transgenic mice) in the development of NF1-associated MPNSTs. The authors cite human gene copy number alteration data, microarray expression data, and TMA analysis to support the relationship between TP53 and EGFR in tumorigenesis.