Publication: Nature. 512(7512): 82-86.
Published Date: August 2014
Characterizes influence of PVT1 in MYC-driven cancers.
Gain of supernumerary copies of the 8q24.21 chromosomal region has been shown to be common in many human cancers and is associated with poor prognosis. In this study, authors show that a single extra copy of myelocytomatosis (MYC) oncogene or a region containing long non-coding RNA gene PVT1 and two other genes fails to significantly advance cancer. However, an extra copy of a segment including all four genes successfully promotes cancer. Using chromosome engineering in mice, the authors highlighted the relationship between PVT1 and MYC as a potential therapeutic target in MYC-driven cancers.