Publication: Cellular and Molecular Bioengineering. 7(3): 379-393.
Published Date: July 2014
Demonstrates efficient reprogramming of human cells on nanofibrous polymeric substrates.
Human induced pluripotent stem (iPS) cells are key resources for drug discovery, regenerative medicine, and tissue engineering. In this study, authors sought to determine how culture substrates impacted reprogramming of human fibroblasts. The authors found that nanofibrous substrates permitted robust attachment of fibroblasts, and reprogramming factor expression helped mitigate any nuclear constraints of substrates. Overall, this study supports the generation of novel substrates that enhance epigenetic reprogramming.